Regiospecific inhibition of DNA duplication by antisense phosphate-methylated oligodeoxynucleotides.

A new synthesis route for long phosphate-methylated oligodeoxynucleotides is described, which were used as antisense inhibitors of the DNA replication. Phosphate-methylated oligomers hybridize more strongly with natural DNA than their natural analogues, due to the absence of electrostatic interstran...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Moody, H M, van Genderen, M H, Koole, L H, Kocken, H J, Meijer, E M, Buck, H M
Формат: Artigo
Язык:Inglês
Опубликовано: 1989
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC318031/
https://ncbi.nlm.nih.gov/pubmed/2748337
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы