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A mouse model of heterogeneous, c-MYC-initiated prostate cancer with loss of Pten and p53
Human tumors are heterogeneous and evolve through a dynamic process of genetic mutation and selection. During this process, the effects of a specific mutation on the incipient cancer cell may dictate the nature of subsequent mutations that can be tolerated or selected for, affecting the rate at whic...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179816/ https://ncbi.nlm.nih.gov/pubmed/21685943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.236 |
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