Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts

BACKGROUND: In around 50% of all human cancers the tumor suppressor p53 is mutated. It is generally assumed that in the remaining tumors the wild-type p53 protein is functionally impaired. The two main inhibitors of p53, hMDM2 (MDM2) and hMDMX (MDMX/MDM4) are frequently overexpressed in wild-type p5...

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Main Authors: Lenos, Kristiaan, de Lange, Job, Teunisse, Amina FAS, Lodder, Kirsten, Verlaan-de Vries, Matty, Wiercinska, Eliza, van der Burg, Marja JM, Szuhai, Karoly, Jochemsen, Aart G
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179748/
https://ncbi.nlm.nih.gov/pubmed/21910853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-111
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