Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice

BACKGROUND: The purpose of this study was to investigate whether localized peripheral inflammation, such as osteoarthritis, contributes to neuroinflammation and neurodegenerative disease in vivo. METHODS: We employed the inducible Col1-IL1β(XAT )mouse model of osteoarthritis, in which induction of o...

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Bibliographische Detailangaben
Hauptverfasser: Kyrkanides, Stephanos, Tallents, Ross H, Miller, Jen-nie H, Olschowka, Mallory E, Johnson, Renee, Yang, Meixiang, Olschowka, John A, Brouxhon, Sabine M, O'Banion, M Kerry
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179730/
https://ncbi.nlm.nih.gov/pubmed/21899735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-8-112
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