IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells

The role of IGF binding protein 2 (IGFBP2) in cell growth is intriguing and largely undefined. Previously we identified IGFBP2 as an extrinsic factor that supports ex vivo expansion of hematopoietic stem cells (HSCs). Here we showed that IGFBP2-null mice have fewer HSCs than wild-type mice. While IG...

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Detalhes bibliográficos
Main Authors: Huynh, HoangDinh, Zheng, Junke, Umikawa, Masato, Zhang, Chaozheng, Silvany, Robert, Iizuka, Satoru, Holzenberger, Martin, Zhang, Wei, Zhang, Cheng Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179393/
https://ncbi.nlm.nih.gov/pubmed/21821709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-331876
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