Calpain-6, a Target Molecule of Glucocorticoids, Regulates Osteoclastic Bone Resorption via Cytoskeletal Organization and Microtubule Acetylation

Glucocorticoids (GCs) inhibit the resorptive capacity of the osteoclast by disrupting its cytoskeleton. We find that calpain-6 (Capn6), a unique, nonproteolytic member of its family, is suppressed 12-fold by dexamethasone (DEX) in the bone-degrading cell. While Capn6 abundance parallels commitment o...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hong, Jung Min, Teitelbaum, Steven L, Kim, Tae-Ho, Ross, F Patrick, Kim, Shin-Yoon, Kim, Hyun-Ju
Format: Artigo
Langue:Inglês
Publié: Wiley Subscription Services, Inc., A Wiley Company 2011
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179291/
https://ncbi.nlm.nih.gov/pubmed/20814968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.241
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