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Arbovirus high fidelity variant loses fitness in mosquitoes and mice

The error rate of RNA-dependent RNA polymerases (RdRp) affects the mutation frequency in a population of viral RNAs. Using chikungunya virus (CHIKV), we describe a unique arbovirus fidelity variant with a single C483Y amino acid change in the nsP4 RdRp that increases replication fidelity and generat...

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Bibliografiske detaljer
Main Authors: Coffey, Lark L., Beeharry, Yasnee, Bordería, Antonio V., Blanc, Hervé, Vignuzzi, Marco
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179076/
https://ncbi.nlm.nih.gov/pubmed/21896755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111650108
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