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Arbovirus high fidelity variant loses fitness in mosquitoes and mice
The error rate of RNA-dependent RNA polymerases (RdRp) affects the mutation frequency in a population of viral RNAs. Using chikungunya virus (CHIKV), we describe a unique arbovirus fidelity variant with a single C483Y amino acid change in the nsP4 RdRp that increases replication fidelity and generat...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179076/ https://ncbi.nlm.nih.gov/pubmed/21896755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111650108 |
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