Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

The zinc-finger antiviral protein (ZAP) was originally identified as a host factor that inhibits the replication of Moloney murine leukemia virus. Here we report that ZAP inhibits HIV-1 infection by promoting the degradation of specific viral mRNAs. Overexpression of ZAP rendered cells resistant to...

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Bibliografiske detaljer
Main Authors: Zhu, Yiping, Chen, Guifang, Lv, Fengxiang, Wang, Xinlu, Ji, Xin, Xu, Yihui, Sun, Jing, Wu, Li, Zheng, Yong-Tang, Gao, Guangxia
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179061/
https://ncbi.nlm.nih.gov/pubmed/21876179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101676108
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