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Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4α

Nuclear xenobiotic receptor CAR activates transcription of the CYP2B6 gene by directly binding to the distal enhancer PBREM. This CAR-mediated activation is synergized by transcription factors EGR1 and HNF4α that bind to the proximal element OARE(KI) [1]. Two additional EGR1 binding sites have now b...

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Hlavní autoři: Inoue, Kaoru, Negishi, Masahiko
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178840/
https://ncbi.nlm.nih.gov/pubmed/19467232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.05.031
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