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Nuclear Receptor CAR Requires Early Growth Response 1 to Activate the Human Cytochrome P450 2B6 Gene

The nuclear receptor CAR (constitutive active/androstane receptor) is a drug-sensing transcription factor, regulating the hepatic genes that encode various drug-metabolizing enzymes. We have now characterized the novel regulatory mechanism by which the signal molecule EGR1 (early growth response 1)...

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Hlavní autoři: Inoue, Kaoru, Negishi, Masahiko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2447624/
https://ncbi.nlm.nih.gov/pubmed/18303024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800729200
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