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A Practical, Enantioselective Synthetic Route to a Key Precursor to the Tetracycline Antibiotics

[Image: see text] A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics is reported. The route proceeds in 9 steps (21% yield) from the commercial substance methyl 3-hydroxy-5-isoxazolecarboxylate. Key steps in the route involve enantioselective addition of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brubaker, Jason D., Myers, Andrew G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3178443/
https://ncbi.nlm.nih.gov/pubmed/17691796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol071377d
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