A Robust Platform for the Synthesis of New Tetracycline Antibiotics

Tetracyclines and tetracycline analogs are prepared by a convergent, single-step Michael–Claisen condensation of the AB precursors 1 or 2 with D-ring precursors of wide structural variability, followed by removal of protective groups (typically in two steps). A number of procedural variants of the k...

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Bibliografiske detaljer
Main Authors: Sun, Cuixiang, Wang, Qiu, Brubaker, Jason D., Wright, Peter M., Lerner, Christian D., Noson, Kevin, Charest, Mark, Siegel, Dionicio R., Wang, Yi-Ming, Myers, Andrew G.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681267/
https://ncbi.nlm.nih.gov/pubmed/19053822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja806629e
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