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A Practical, Enantioselective Synthetic Route to a Key Precursor to the Tetracycline Antibiotics
[Image: see text] A practical, enantioselective synthetic route to a key precursor to the tetracycline antibiotics is reported. The route proceeds in 9 steps (21% yield) from the commercial substance methyl 3-hydroxy-5-isoxazolecarboxylate. Key steps in the route involve enantioselective addition of...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178443/ https://ncbi.nlm.nih.gov/pubmed/17691796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol071377d |
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