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p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
p53 mutations, occurring in two-thirds of all human cancers, confer a gain of function phenotype, including the ability to form metastasis, the determining feature in the prognosis of most human cancer. This effect seems mediated at least partially by its ability to physically interact with p63, thu...
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178431/ https://ncbi.nlm.nih.gov/pubmed/21760596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.81 |
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