Prevention of chain cleavage in the chemical synthesis of 2'-silylated oligoribonucleotides.
Strong aqueous ammonium hydroxide used to remove N-acyl protecting groups from synthetic oligoribonucleotides causes removal of some alkylsilyl protecting groups from 2'-hydroxyls and leads to chain cleavage. This problem is most severe when 30% ammonium hydroxide is used and substantially reduced b...
Kaydedildi:
| Yayımlandı: | Nucleic Acids Res |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
1989
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| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317792/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2726485/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.9.3501 |
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