Chemical synthesis of biologically active oligoribonucleotides using beta-cyanoethyl protected ribonucleoside phosphoramidites.

The preparation of fully protected diisopropylamino-beta-cyanoethyl ribonucleoside phosphoramidites with regioisomeric purity greater than 99.95% is described. It is demonstrated that the combination of standard DNA protecting groups, 5'-O-DMT, N-Bz (Ade and Cyt), N-iBu (Gua), beta-cyanoethyl f...

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Bibliografiska uppgifter
Huvudupphovsmän: Scaringe, S A, Francklyn, C, Usman, N
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1990
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC332221/
https://ncbi.nlm.nih.gov/pubmed/2216717
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