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Prevention of chain cleavage in the chemical synthesis of 2'-silylated oligoribonucleotides.

Strong aqueous ammonium hydroxide used to remove N-acyl protecting groups from synthetic oligoribonucleotides causes removal of some alkylsilyl protecting groups from 2'-hydroxyls and leads to chain cleavage. This problem is most severe when 30% ammonium hydroxide is used and substantially redu...

詳細記述

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書誌詳細
出版年:Nucleic Acids Res
主要な著者: Wu, T, Ogilvie, K K, Pon, R T
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 1989
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317792/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2726485/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.9.3501
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