Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge

Immunization with Ft-LPS provokes an antigen-specific, B-1a cell-derived antibody response that protects WT mice against an otherwise lethal challenge with Ft LVS. However, this same regimen offers limited protection to TLR2(−/−) mice, despite production of WT levels of anti-Ft-LPS antibodies. As Ft...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Cole, Leah E., Mann, Barbara J., Shirey, Kari Ann, Richard, Katharina, Yang, Yang, Gearhart, Patricia J., Chesko, Kirsty L., Viscardi, Rose M., Vogel, Stefanie N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Leukocyte Biology 2011
Aiheet:
Host Defense & Pathophysiology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177696/
https://ncbi.nlm.nih.gov/pubmed/21750122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0111014
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