Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling

TLR2 plays a central role in the activation of innate immunity in response to Ft, the causative agent of tularemia. We reported previously that Ft LVS elicited strong, dose-dependent NF-κB reporter activity in TLR2-expressing human embryo kidney 293 T cells and that Ft LVS-induced murine macrophage...

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Autori principali: Cole, Leah E., Laird, Michelle H. W., Seekatz, Anna, Santiago, Araceli, Jiang, Zhaozhao, Barry, Eileen, Shirey, Kari Ann, Fitzgerald, Katherine A., Vogel, Stefanie N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Society for Leukocyte Biology 2010
Soggetti:
Receptors, Signal Transduction, & Genes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812562/
https://ncbi.nlm.nih.gov/pubmed/19889726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0909619
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