Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca(2+) release

Chemokines induce calcium (Ca(2+)) signaling and chemotaxis in dendritic cells (DCs), but the molecular players involved in shaping intracellular Ca(2+) changes remain to be characterized. Using siRNA and knockout mice, we show that in addition to inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+)...

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Hauptverfasser: Sumoza-Toledo, Adriana, Lange, Ingo, Cortado, Hanna, Bhagat, Harivadan, Mori, Yasuo, Fleig, Andrea, Penner, Reinhold, Partida-Sánchez, Santiago
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2011
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177582/
https://ncbi.nlm.nih.gov/pubmed/21753080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-178483
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