The human DEK oncogene regulates DNA damage response signaling and repair

The human DEK gene is frequently overexpressed and sometimes amplified in human cancer. Consistent with oncogenic functions, Dek knockout mice are partially resistant to chemically induced papilloma formation. Additionally, DEK knockdown in vitro sensitizes cancer cells to DNA damaging agents and in...

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Autori principali: Kavanaugh, Gina M., Wise-Draper, Trisha M., Morreale, Richard J., Morrison, Monique A., Gole, Boris, Schwemberger, Sandy, Tichy, Elisia D., Lu, Lu, Babcock, George F., Wells, James M., Drissi, Rachid, Bissler, John J., Stambrook, Peter J., Andreassen, Paul R., Wiesmüller, Lisa, Wells, Susanne I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177200/
https://ncbi.nlm.nih.gov/pubmed/21653549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr454
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