The human DEK oncogene regulates DNA damage response signaling and repair

The human DEK gene is frequently overexpressed and sometimes amplified in human cancer. Consistent with oncogenic functions, Dek knockout mice are partially resistant to chemically induced papilloma formation. Additionally, DEK knockdown in vitro sensitizes cancer cells to DNA damaging agents and in...

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書誌詳細
主要な著者: Kavanaugh, Gina M., Wise-Draper, Trisha M., Morreale, Richard J., Morrison, Monique A., Gole, Boris, Schwemberger, Sandy, Tichy, Elisia D., Lu, Lu, Babcock, George F., Wells, James M., Drissi, Rachid, Bissler, John J., Stambrook, Peter J., Andreassen, Paul R., Wiesmüller, Lisa, Wells, Susanne I.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2011
主題:
Genome Integrity, Repair and Replication
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177200/
https://ncbi.nlm.nih.gov/pubmed/21653549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr454
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