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Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism

Riboswitches regulate gene expression via ligand binding to an aptamer domain which induces conformational changes in a regulatory expression platform. By unfolding and refolding single add adenine riboswitch molecules in an optical trap, an integrated picture of the folding was developed and relate...

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Bibliografische gegevens
Hoofdauteurs: Neupane, Krishna, Yu, Hao, Foster, Daniel A. N., Wang, Feng, Woodside, Michael T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2011
Onderwerpen:
RNA
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3177178/
https://ncbi.nlm.nih.gov/pubmed/21653559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr305
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