Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis

In response to deregulated oncogene activation, mammalian cells activate disposal programs such as programmed cell death. To investigate the mechanisms behind this oncogenic stress response we used Bcr-Abl over-expressing cells cultivated in presence of imatinib. Imatinib deprivation led to rapid in...

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Detaylı Bibliyografya
Asıl Yazarlar: Dengler, Michael A., Staiger, Annette M., Gutekunst, Matthias, Hofmann, Ute, Doszczak, Malgorzata, Scheurich, Peter, Schwab, Matthias, Aulitzky, Walter E., van der Kuip, Heiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3176818/
https://ncbi.nlm.nih.gov/pubmed/21949869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025139
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