The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells

BACKGROUND: The inhibition of Breast Cancer 1 (BRCA1) expression sensitizes breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically relevant agents that target BRCA1 expression have not been identified. Our recent report suggested the potential of the histone deacetylase (...

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Hlavní autoři: Weberpals, Johanne I, O'Brien, Anna M, Niknejad, Nima, Garbuio, Kyla D, Clark-Knowles, Katherine V, Dimitroulakos, Jim
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Primary Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175148/
https://ncbi.nlm.nih.gov/pubmed/21854619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-11-29
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