The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells

BACKGROUND: The inhibition of Breast Cancer 1 (BRCA1) expression sensitizes breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically relevant agents that target BRCA1 expression have not been identified. Our recent report suggested the potential of the histone deacetylase (...

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Main Authors: Weberpals, Johanne I, O'Brien, Anna M, Niknejad, Nima, Garbuio, Kyla D, Clark-Knowles, Katherine V, Dimitroulakos, Jim
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Primary Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175148/
https://ncbi.nlm.nih.gov/pubmed/21854619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-11-29
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