β1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation

β1 integrin tyrosine phosphorylation by oncogenic kinases, such as Src, has been predicted to induce tumorigenesis by disrupting adhesion and modifying integrin signaling. We directly tested this hypothesis by subjecting mice with “nonphosphorylatable” tyrosine-to-phenylalanine substitutions in the...

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Detaylı Bibliyografya
Asıl Yazarlar: Meves, Alexander, Geiger, Tamar, Zanivan, Sara, DiGiovanni, John, Mann, Matthias, Fässler, Reinhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174600/
https://ncbi.nlm.nih.gov/pubmed/21876123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105689108
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