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β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in epidermis
β1 integrin adhesion is believed to require binding of talins and kindlins to the membrane proximal and distal NPxY motifs of the β1 cytoplasmic tail, respectively. To test this hypothesis we substituted the membrane proximal and distal tyrosines (Y) of the β1 tail with alanine (A) residues (β1 Y783...
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| Udgivet i: | J Invest Dermatol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535429/ https://ncbi.nlm.nih.gov/pubmed/23702582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.232 |
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