Mutations in the Paxillin-binding Site of Integrin-linked Kinase (ILK) Destabilize the Pseudokinase Domain and Cause Embryonic Lethality in Mice

Integrin-linked kinase (ILK) localizes to focal adhesions (FAs) where it regulates cell spreading, migration, and growth factor receptor signaling. Previous reports showed that overexpressed ILK in which Val(386) and Thr(387) were substituted with glycine residues (ILK-VT/GG) could neither interact...

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Detalhes bibliográficos
Main Authors: Moik, Daniel, Böttcher, Anika, Makhina, Tatiana, Grashoff, Carsten, Bulus, Nada, Zent, Roy, Fässler, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696662/
https://ncbi.nlm.nih.gov/pubmed/23658024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470476
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