Mutations in the Paxillin-binding Site of Integrin-linked Kinase (ILK) Destabilize the Pseudokinase Domain and Cause Embryonic Lethality in Mice

Integrin-linked kinase (ILK) localizes to focal adhesions (FAs) where it regulates cell spreading, migration, and growth factor receptor signaling. Previous reports showed that overexpressed ILK in which Val(386) and Thr(387) were substituted with glycine residues (ILK-VT/GG) could neither interact...

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Bibliografiske detaljer
Main Authors: Moik, Daniel, Böttcher, Anika, Makhina, Tatiana, Grashoff, Carsten, Bulus, Nada, Zent, Roy, Fässler, Reinhard
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696662/
https://ncbi.nlm.nih.gov/pubmed/23658024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470476
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