Mutations in the Paxillin-binding Site of Integrin-linked Kinase (ILK) Destabilize the Pseudokinase Domain and Cause Embryonic Lethality in Mice

Integrin-linked kinase (ILK) localizes to focal adhesions (FAs) where it regulates cell spreading, migration, and growth factor receptor signaling. Previous reports showed that overexpressed ILK in which Val(386) and Thr(387) were substituted with glycine residues (ILK-VT/GG) could neither interact...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Moik, Daniel, Böttcher, Anika, Makhina, Tatiana, Grashoff, Carsten, Bulus, Nada, Zent, Roy, Fässler, Reinhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696662/
https://ncbi.nlm.nih.gov/pubmed/23658024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470476
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi