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Kedarcidin Chromophore–Synthesis of Its Proposed Structure and Evidence for a Stereochemical Revision

A convergent, enantioselective synthesis of the proposed structure of kedarcidin chromophore (1) is described. The route is 24 steps in the longest linear sequence (beginning with the commercial reagent 2,3-O-isopropylidene-d-erythronolactone) with an average yield of 75% per step (overall yield: 0....

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Detalhes bibliográficos
Main Authors: Ren, Feng, Hogan, Philip C., Anderson, Alan J., Myers, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174495/
https://ncbi.nlm.nih.gov/pubmed/17417855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja071205b
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