Agonist-selective patterns of µ-opioid receptor phosphorylation revealed by phosphosite-specific antibodies

BACKGROUND AND PURPOSE: Morphine activates the µ-opioid receptor without causing its rapid endocytosis. In contrast, full agonists such as [d-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO) or etonitazene stimulate a rapid and profound internalization. However, the detailed molecular events underlying the...

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Main Authors: Doll, Christian, Konietzko, Jens, Pöll, Florian, Koch, Thomas, Höllt, Volker, Schulz, Stefan
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2011
Teme:
Research Papers with Commentaries
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174411/
https://ncbi.nlm.nih.gov/pubmed/21449911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01382.x
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