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Essential Domains of ADAMTS13 Metalloprotease Required for Modulation of Arterial Thrombosis

OBJECTIVE: ADAMTS13 inhibits platelet aggregation and arterial thrombosis by cleavage of von Willebrand factor (VWF). However, the structural components of ADAMTS13 required for inhibition of arterial thrombosis are not fully defined. METHODS AND RESULTS: Using recombinant proteins and a murine mode...

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Autori principali: Xiao, Juan, Jin, Sheng-Yu, Xue, Jing, Sorvillo, Nicoletta, Voorberg, Jan, Zheng, X. Long
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174348/
https://ncbi.nlm.nih.gov/pubmed/21799176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.229609
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