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Essential Domains of ADAMTS13 Metalloprotease Required for Modulation of Arterial Thrombosis

OBJECTIVE: ADAMTS13 inhibits platelet aggregation and arterial thrombosis by cleavage of von Willebrand factor (VWF). However, the structural components of ADAMTS13 required for inhibition of arterial thrombosis are not fully defined. METHODS AND RESULTS: Using recombinant proteins and a murine mode...

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Detalhes bibliográficos
Main Authors: Xiao, Juan, Jin, Sheng-Yu, Xue, Jing, Sorvillo, Nicoletta, Voorberg, Jan, Zheng, X. Long
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174348/
https://ncbi.nlm.nih.gov/pubmed/21799176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.229609
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