Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

BACKGROUND: The majority of patients diagnosed with thrombotic thrombocytopenic purpura have autoantibodies directed towards the spacer domain of ADAMTS13. DESIGN AND METHODS: In this study we explored the epitope specificity and immunoglobulin class and immunoglobulin G subclass distribution of ant...

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Autores principales: Pos, Wouter, Sorvillo, Nicoletta, Fijnheer, Rob, Feys, Hendrik B., Kaijen, Paul H.P, Vidarsson, Gestur, Voorberg, Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2011
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208685/
https://ncbi.nlm.nih.gov/pubmed/21712537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.036327
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