Replication Protein A (RPA) Hampers the Processive Action of APOBEC3G Cytosine Deaminase on Single-Stranded DNA

BACKGROUND: Editing deaminases have a pivotal role in cellular physiology. A notable member of this superfamily, APOBEC3G (A3G), restricts retroviruses, and Activation Induced Deaminase (AID) generates antibody diversity by localized deamination of cytosines in DNA. Unconstrained deaminase activity...

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Main Authors: Lada, Artem G., Waisertreiger, Irina S.-R., Grabow, Corinn E., Prakash, Aishwarya, Borgstahl, Gloria E. O., Rogozin, Igor B., Pavlov, Youri I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174200/
https://ncbi.nlm.nih.gov/pubmed/21935481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024848
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