Lucanthone and Its Derivative Hycanthone Inhibit Apurinic Endonuclease-1 (APE1) by Direct Protein Binding

Lucanthone and hycanthone are thioxanthenone DNA intercalators used in the 1980s as antitumor agents. Lucanthone is in Phase I clinical trial, whereas hycanthone was pulled out of Phase II trials. Their potential mechanism of action includes DNA intercalation, inhibition of nucleic acid biosyntheses...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Naidu, Mamta D., Agarwal, Rakhi, Pena, Louis A., Cunha, Luis, Mezei, Mihaly, Shen, Min, Wilson, David M., Liu, Yuan, Sanchez, Zina, Chaudhary, Pankaj, Wilson, Samuel H., Waring, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174134/
https://ncbi.nlm.nih.gov/pubmed/21935361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023679
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados