Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo

We have developed a dual bioluminescent reporter system allowing noninvasive, concomitant imaging of T-cell trafficking, expansion, and activation of nuclear factor of activated T cells (NFAT) in vivo. NFAT activation plays an important role in T-cell activation and T-cell development. Therefore we...

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Detalhes bibliográficos
Main Authors: Na, Il-Kang, Markley, John C., Tsai, Jennifer J., Yim, Nury L., Beattie, Bradley J., Klose, Alexander D., Holland, Amanda M., Ghosh, Arnab, Rao, Uttam K., Stephan, Matthias T., Serganova, Inna, Santos, Elmer B., Brentjens, Renier J., Blasberg, Ronald G., Sadelain, Michel, van den Brink, Marcel R. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173994/
https://ncbi.nlm.nih.gov/pubmed/20511541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-259432
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