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The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse

The Bordetella pertussis adenylate cyclase toxin (CyaA) assists infection by potently suppressing the host immune response. Although CyaA effectively targets T lymphocytes, its putative receptor on these cells is unknown. Here, we show that CyaA binds to T cells via the β(2) integrin LFA-1 in its ac...

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Detalhes bibliográficos
Main Authors: Paccani, Silvia Rossi, Finetti, Francesca, Davi, Marilyne, Patrussi, Laura, D'Elios, Mario M., Ladant, Daniel, Baldari, Cosima T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173238/
https://ncbi.nlm.nih.gov/pubmed/21576384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20101558
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