Inhibition of Protein-tyrosine Phosphatase 1B (PTP1B) Mediates Ubiquitination and Degradation of Bcr-Abl Protein

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized at the molecular level by the expression of Bcr-Abl, a chimeric protein with deregulated tyrosine kinase activity. The protein-tyrosine phosphatase 1B (PTP1B) is up-regulated in Bcr-Abl-expressing cells, suggesting a r...

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Bibliographic Details
Main Authors: Alvira, Daniel, Naughton, Ruth, Bhatt, Lavinia, Tedesco, Sara, Landry, William D., Cotter, Thomas G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173167/
https://ncbi.nlm.nih.gov/pubmed/21795709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249060
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