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Crystal Structures of Complexes with Cobalt-Reconstituted Human Arginase I(,)

The binuclear manganese metalloenzyme human arginase I (HAI) is a potential protein drug for cancer chemotherapy, in that it is capable of depleting extracellular l-Arg levels in the microenvironment of tumor cells that require this nutrient to thrive. Substitution of the native Mn(2+)(2) cluster wi...

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Bibliografiske detaljer
Main Authors: D’Antonio, Edward L., Christianson, David W.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172387/
https://ncbi.nlm.nih.gov/pubmed/21870783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201101t
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