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Binding of the unreactive substrate analog l-2-amino-3-guanidinopropionic acid (dinor-l-arginine) to human arginase I
Human arginase I (HAI) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea through a metal-activated hydroxide mechanism. Since HAI regulates l-Arg bioavailability for NO biosynthesis, it is a potential drug target for the treatment of card...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412766/ https://ncbi.nlm.nih.gov/pubmed/22869115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112027820 |
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