Binding of the unreactive substrate analog l-2-amino-3-guanidinopropionic acid (dinor-l-arginine) to human arginase I

Human arginase I (HAI) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea through a metal-activated hydroxide mechanism. Since HAI regulates l-Arg bioavailability for NO biosynthesis, it is a potential drug target for the treatment of card...

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Bibliographic Details
Main Authors: D’Antonio, Edward L., Christianson, David W.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2012
Subjects:
Structural Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412766/
https://ncbi.nlm.nih.gov/pubmed/22869115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112027820
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