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Crystal Structures of Complexes with Cobalt-Reconstituted Human Arginase I(,)
The binuclear manganese metalloenzyme human arginase I (HAI) is a potential protein drug for cancer chemotherapy, in that it is capable of depleting extracellular l-Arg levels in the microenvironment of tumor cells that require this nutrient to thrive. Substitution of the native Mn(2+)(2) cluster wi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172387/ https://ncbi.nlm.nih.gov/pubmed/21870783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201101t |
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