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Synthesis of Novel β-Lactone Inhibitors of Fatty Acid Synthase
Fatty acid synthase (FAS) is necessary for growth and survival of tumor cells and is a promising drug target for oncology. Here, we report on the syntheses and activity of novel inhibitors of the thioesterase domain of FAS. Using the structure of orlistat as a starting point, which contains a β-lact...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172131/ https://ncbi.nlm.nih.gov/pubmed/18710210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800321h |
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