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Synthesis of Novel β-Lactone Inhibitors of Fatty Acid Synthase

Fatty acid synthase (FAS) is necessary for growth and survival of tumor cells and is a promising drug target for oncology. Here, we report on the syntheses and activity of novel inhibitors of the thioesterase domain of FAS. Using the structure of orlistat as a starting point, which contains a β-lact...

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Bibliografische gegevens
Hoofdauteurs: Richardson, Robyn D., Ma, Gil, Oyola, Yatsandra, Zancanella, Manuel, Knowles, Lynn M., Cieplak, Piotr, Romo, Daniel, Smith, Jeffrey W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172131/
https://ncbi.nlm.nih.gov/pubmed/18710210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800321h
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