Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression

Pancreatic ductal adenocarcinoma (PDAC) is associated with a pronounced collagen-rich fibrosis known as desmoplastic reaction; however the role of fibrosis in PDAC is poorly understood. In this report we show that collagen can regulate the tumor suppressive let-7 family of microRNAs in pancreatic ca...

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Hauptverfasser: Dangi-Garimella, Surabhi, Strouch, Matthew J., Grippo, Paul J., Bentrem, David J., Munshi, Hidayatullah G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172057/
https://ncbi.nlm.nih.gov/pubmed/21057545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.485
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