MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling

Pancreatic cancer is associated with a pronounced fibrotic reaction that was recently shown to limit delivery of chemotherapy. To identify potential therapeutic targets to overcome this fibrosis, we examined the interplay between fibrosis and the key proteinase membrane type 1-matrix metalloproteina...

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Autors principals: Krantz, Seth B., Shields, Mario A., Dangi-Garimella, Surabhi, Cheon, Eric C., Barron, Morgan R., Hwang, Rosa F., Rao, M. Sambasiva, Grippo, Paul J., Bentrem, David J., Munshi, Hidayatullah G.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196812/
https://ncbi.nlm.nih.gov/pubmed/21856775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0023
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