Three dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2

One of the hallmarks of human pancreatic ductal adenocarcinoma (PDAC) is its pronounced type I collagen-rich fibrotic reaction. Although recent reports have shown that the fibrotic reaction can limit the efficacy of gemcitabine chemotherapy, the underlying mechanisms remain poorly understood. In thi...

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Main Authors: Dangi-Garimella, Surabhi, Krantz, Seth B., Barron, Morgan R., Shields, Mario A., Heiferman, Michael J., Grippo, Paul J., Bentrem, David J., Munshi, Hidayatullah G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076124/
https://ncbi.nlm.nih.gov/pubmed/21148071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1855
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