MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling

Pancreatic cancer is associated with a pronounced fibrotic reaction that was recently shown to limit delivery of chemotherapy. To identify potential therapeutic targets to overcome this fibrosis, we examined the interplay between fibrosis and the key proteinase membrane type 1-matrix metalloproteina...

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Detaylı Bibliyografya
Asıl Yazarlar: Krantz, Seth B., Shields, Mario A., Dangi-Garimella, Surabhi, Cheon, Eric C., Barron, Morgan R., Hwang, Rosa F., Rao, M. Sambasiva, Grippo, Paul J., Bentrem, David J., Munshi, Hidayatullah G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196812/
https://ncbi.nlm.nih.gov/pubmed/21856775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-11-0023
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