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Binding of the Complexin N terminus to the SNARE complex potentiates synaptic vesicle fusogenicity
Complexins facilitate and inhibit neurotransmitter release through distinct domains, and their function was proposed to be coupled to the Ca(2+) sensor Synaptotagmin-1. However, the mechanisms underlying Complexin function remain unclear. We now uncover an interaction between the Complexin N terminu...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172005/ https://ncbi.nlm.nih.gov/pubmed/20400951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1791 |
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