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Binding of the Complexin N terminus to the SNARE complex potentiates synaptic vesicle fusogenicity

Complexins facilitate and inhibit neurotransmitter release through distinct domains, and their function was proposed to be coupled to the Ca(2+) sensor Synaptotagmin-1. However, the mechanisms underlying Complexin function remain unclear. We now uncover an interaction between the Complexin N terminu...

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Библиографические подробности
Главные авторы: Xue, Mingshan, Craig, Timothy K., Xu, Junjie, Chao, Hsiao-Tuan, Rizo, Josep, Rosenmund, Christian
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172005/
https://ncbi.nlm.nih.gov/pubmed/20400951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1791
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