Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD

The P2X7 receptor participates in purinergic signaling, which may promote the progression of ADPKD. We examined the effects of a P2X7 receptor antagonist and a P2X7 receptor agonist on cyst development in a zebrafish model of polycystic kidney disease in which we knocked down pkd2 by morpholinos. We...

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Autors principals: Chang, Ming-Yang, Lu, Jenn-Kan, Tian, Ya-Chung, Chen, Yung-Chang, Hung, Cheng-Chieh, Huang, Yi-Hui, Chen, Yau-Hung, Wu, Mai-Szu, Yang, Chih-Wei, Cheng, Yi-Chuan
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2011
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171940/
https://ncbi.nlm.nih.gov/pubmed/21636640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010070728
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